Matthew McConaugheyJoseph "Coop" Cooper
Anne HathawayDr. Amelia Brand
Jessica ChastainMurphy "Murph" Cooper
Michael CaineProfessor John Brand
Bill IrwinTARS (voice)
Ellen BurstynOld Murph
Mackenzie FoyYoung Murph
Casey AffleckTom Cooper
John LithgowDonald
Wes BentleyDoyle
David GyasiRomilly
Matt DamonMann
Topher GraceGetty
Timothée ChalametYoung Tom
David OyelowoSchool Principal
William DevaneWilliams
Josh StewartCASE (voice)
Collette WolfeMs. Hanley
Leah CairnsLois
Russ FegaCrew Chief
Lena GeorgasNurse Practitioner
Jeff HephnerDoctor
Elyes GabelAdministrator
Brooke SmithNurse
Liam DickinsonCoop
Francis X. McCarthyBoots
Andrew BorbaSmith
Flora NolanGirl on Truck
Griffen FraserBoy on Truck
William Patrick BrownNASA Employee (uncredited)
Kristian Van der HeydenScientist (uncredited)
Joseph OliveiraAstronaut (uncredited)
Ryan IrvingPopcorn Seller (uncredited)
Alexander Michael HelisekConstruction Boss (uncredited)
Benjamin HardyNASA Scientist (uncredited)