Nathan FillionMalcolm "Mal" Reynolds
Summer GlauRiver Tam
Gina TorresZoë Alleyne Washburne
Alan TudykHoban "Wash" Washburne
Morena BaccarinInara Serra
Adam BaldwinJayne Cobb
Jewel StaiteKaywinnet Lee "Kaylee" Frye
Sean MaherSimon Tam
Ron GlassShepherd Derrial Book
Chiwetel EjioforThe Operative
David KrumholtzMr. Universe
Michael HitchcockDr. Mathias
Sarah PaulsonDr. Caron
Yan FeldmanMingojerry "Mingo" Rample
Rafael FeldmanFantastic "Fanty" Rample
Nectar RoseLenore
Tamara TaylorTeacher
Glenn HowertonLilac Young Tough
Hunter Ansley WrynYoung River Tam
Logan O'BrienBoy Student
Erik ErotasBoy Student
Demetra RavenGirl Student
Marley McCleanGirl Student
Jessica HuangGirl Student
Scott KinworthyEnsign
Erik WeinerHelmsman
Conor O'BrienLab Technician
Peter James SmithLab Technician
Weston NathansonTrade Agent
Carrie "CeCe" ClineYoung Female Intern
Chuck O'NeilVault Guard
Amy WieczorekLilac Mom
Tristan JarredLilac Son
Elaine Mani LeeFan Dancer
Terrence Hardy Jr.Mining Camp Boy
Brian O'HareAlliance Pilot
Ryan TaszBlack Room Soldier
Colin Patrick LynchBlack Room Soldier
Terrell TilfordNews Anchor
Joshua Michael KwiatSlovenly Beaumonde Man
Antonio RufinoBartender (uncredited)
Linda WangChinese Snake Dancer (uncredited)
Rick WilliamsonBar Guy (uncredited)
Neil Patrick HarrisScreaming Reaver (uncredited)
Matt McColmLab Security (uncredited)
Marcus YoungBar Security (uncredited)
Dennis KeifferBar Guy (uncredited)