Steve CarellGru (voice)
Jason SegelVector (voice)
Miranda CosgroveMargo (voice)
Elsie FisherAgnes (voice)
Dana GaierEdith (voice)
Russell BrandDr. Nefario (voice)
Julie AndrewsGru's Mother (voice)
Will ArnettMr. Perkins (voice)
Kristen WiigMiss Hattie (voice)
Pierre CoffinTim / Bob / Mark / Phil / Stuart (voice)
Chris RenaudDave (voice)
Jemaine ClementJerry (voice)
Jack McBrayerCarnival Barker / Tourist Dad (voice)
Danny McBrideFred McDade (voice)
Mindy KalingTourist Mom (voice)
Rob HuebelAnchorman (voice)
Ken DaurioEgyptian Guard (voice)
Ken JeongTalk Show Host (voice)
Charles BrightAdditional Voices (voice)
Katie LeighAdditional Voices (voice)
Ranjani BrowAdditional Voices (voice)
Scott MenvilleAdditional Voices (voice)
Holly DorffAdditional Voices (voice)
Edie MirmanAdditional Voices (voice)
Jackie GonneauAdditional Voices (voice)
Al RodrigoAdditional Voices (voice)
Wendy HoffmannAdditional Voices (voice)
Jakob RostonAdditional Voices (voice)
James KysonAdditional Voices (voice)
John Hans TesterAdditional Voices (voice)
Tony LeeAdditional Voices (voice)
Debi Mae WestAdditional Voices (voice)