Ryan ReynoldsWade Wilson / Deadpool
Morena BaccarinVanessa
Ed SkreinAjax
T.J. MillerWeasel
Gina CaranoAngel Dust
Leslie UggamsBlind Al
Brianna HildebrandNegasonic Teenage Warhead
Karan SoniDopinder
Jed ReesRecruiter
Stefan KapičićColossus (voice)
Randal ReederBuck
Isaac C. Singleton Jr.Boothe
Michael BenyaerWarlord
Style DayneJeremy (Pizza Guy)
Kyle CassieGavin Merchant
Taylor HicksonMeghan Orlovsky
AyzeeTeen Girl #1
Naika ToussaintTeen Girl #2
Justyn ShippeltArcade Ticket Taker
Donna YamamotoOncologist
Hugh ScottDavid Cunningham
Cindy PiperChinatown Merchant
Em HaineWhisper Girlfriend
Aatash AmirWhisper Boyfriend
Chad RileyPool Hall Goon
Paul BelsitoFight Club Boss
Darcey JohnsonGarbage Truck Driver
Kyle RideoutSuper Soldier #1
Jason William DaySuper Soldier #2
Stan LeeStrip Club DJ
Benjamin WilkinsonNo5 Orange Manager
Rachel SheenStrip Club Worker
Paul LazenbyFlight Deck Guard
Rob HayterBob
Andre TricoteuxOn-Set Colossus (uncredited)
Victoria De MareStripper (uncredited)
Heather Ashley ChaseStripclub Pole Performer (uncredited)
Kayla AdamsWaitress Kelly (uncredited)
Olesia ShewchukGuadalajaran Mother (uncredited)
Fabiola ColmeneroGuadalajaran Nurse (uncredited)
Matthew HoglieStrip Club Patron (uncredited)