Antonio BanderasPuss in Boots (voice)
Salma Hayek PinaultKitty Softpaws (voice)
Zach GalifianakisHumpty Dumpty (voice)
Billy Bob ThorntonJack (voice)
Amy SedarisJill (voice)
Constance MarieImelda (voice)
Mike MitchellAndy Beanstalk (voice)
Rich DietlBounty Hunter (voice)
Guillermo del ToroComandante / Hombre del bigote (voice)
Conrad VernonRaoul / Soldier (voice)
Chris MillerLittle Boy Blue / Friar Miller / Prison Guard / Manuel / Rafael (voice)
Ryan CregoLuis (voice)
Tom WheelerBartender / Mean Boy / Wagon Driver / Hotel Owner / Rodrigo (voice)
Tom McGrathBar Thief (voice)
Bob JolesGiuseppe (voice)
Latifa OuaouCrazy Woman / Mean Girl / Milk Lady / Little Boy (voice)
Jessica SchulteEstella Maria (voice)
Bob PersichettiOhhh Cat (voice)
Nina BarryIvana / Charo (voice)
Sergio BrunaSoldier (voice) (uncredited)
Roberto DonatiVarious (voice) (uncredited)
Rebecca DavisVarious Cats (voice) (uncredited)
Joshua RushAdditional Voices (voice) (uncredited)
Lara Jill MillerAdditional Voices (voice) (uncredited)
Jossara JinaroAdditional Voices (voice) (uncredited)
Julie WittnerVarious Cats (voice) (uncredited)