Steve CarellGru (voice)
Pierre CoffinKevin / Stuart / Bob / Minions (voice)
Alan ArkinWild Knuckles (voice)
Taraji P. HensonBelle Bottom (voice)
Michelle YeohMaster Chow (voice)
Julie AndrewsGru's Mom (voice)
Russell BrandDr. Nefario (voice)
Jean-Claude Van DammeJean Clawed (voice)
Dolph LundgrenSvengeance (voice)
Danny TrejoStronghold (voice)
Lucy LawlessNun-Chuck (voice)
Jimmy O. YangHenchman 1 (voice)
Kevin Michael RichardsonHenchman 2 (voice)
John DiMaggioHenchman 3 (voice)
RZABiker (voice)
Michael BeattieVNC Announcer / Guru Rick (voice)
Will ArnettMr. Perkins (voice)
Steve CooganSilas Ramsbottom (voice)
Colette WhitakerGru's Teacher (voice)
Raymond S. PersiBirthday Kid (voice)
Kyle BaldaAdditional Voices (voice)
Bob BergenAdditional Voices (voice)
Beau BillingsleaAdditional Voices (voice)
Cathy CavadiniAdditional Voices (voice)
David ChenAdditional Voices (voice)
Will CollyerAdditional Voices (voice)
Meilee CondronAdditional Voices (voice)
Antonio Raul GarciaAdditional Voices (voice)
Debi DerryberryAdditional Voices (voice)
Scarlett EstevezAdditional Voices (voice)
Kellen GoffAdditional Voices (voice)
Jake GreenAdditional Voices (voice)
Isa HallAdditional Voices (voice)
Ramone HamiltonAdditional Voices (voice)
Aaron HendryAdditional Voices (voice)
Barbara HarrisAdditional Voices (voice)
JP KarliakAdditional Voices (voice)
Evan KishiyamaAdditional Voices (voice)
Sam LavagninoAdditional Voices (voice)
Dawnn LewisAdditional Voices (voice)
Amari McCoyAdditional Voices (voice)
Levi NunezAdditional Voices (voice)
Benjamin PlessalaAdditional Voices (voice)
Alex PuccinelliAdditional Voices (voice)
David J. RandolphAdditional Voices (voice)
Carla RemppAdditional Voices (voice)
Nev ScharrelAdditional Voices (voice)
James SieAdditional Voices (voice)
Mindy SterlingAdditional Voices (voice)
Fred TatascioreAdditional Voices (voice)
Regina TaufenAdditional Voices (voice)
Nisa WardAdditional Voices (voice)
Debra WilsonAdditional Voices (voice)
Nora WymanAdditional Voices (voice)