Ryan ReynoldsWade Wilson / Deadpool / Nicepool
Hugh JackmanLogan / Wolverine
Emma CorrinCassandra Nova
Matthew MacfadyenMr. Paradox
Dafne KeenLaura / X-23
Jon FavreauHappy Hogan
Morena BaccarinVanessa
Rob DelaneyPeter
Leslie UggamsBlind Al
Jennifer GarnerElektra
Wesley SnipesBlade
Channing TatumGambit
Chris EvansJohnny Storm
Henry CavillThe Cavillrine
Wunmi MosakuB-15
Aaron StanfordPyro
Tyler ManeSabretooth
Karan SoniDopinder
Brianna HildebrandNegasonic Teenage Warhead
Shioli KutsunaYukio
Stefan KapičićColossus (voice)
Randal ReederBuck
Lewis TanShatterstar
Nick PauleyDancepool
Sonita HenryMrs. Chipman
Ryan McKenMr. Chipman
Nanak PhloraElliot Chipman
Aydin AhmedKevin Chipman
Leemore Marrett Jr.Minuteman Leader
James DrydenTVA Tech
Ollie PalmerBar Patron
Greg HemphillSeedy Bartender
Aaron W ReedJuggernaut
Mike WatersBlob
Rob McElhenneyTVA Soldier
James ReynoldsScreaming Mutant (voice)
Ed KearOutpost Tech
Paul G. RaymondTVA Office Agent
Blake LivelyLadypool (voice)
Inez ReynoldsKidpool (voice)
Nathan FillionHeadpool (voice)
Matthew McConaugheyCowboypool (voice)
OIin ReynoldsBabypool (voice)
Paul MullinWelshpool
Alex KyshkovychCanadapool
Chris HemsworthThor Odinson (archive footage) (uncredited)
Billy ClementsRussian (uncredited)
Daniel Medina RamosToad (uncredited)
Jade LyeLady Deathstrike (uncredited)
Nilly CetinQuill (uncredited)
Eduardo Gago MuñozAzazel (uncredited)
Chloe KibbleCallisto (uncredited)
Curtis Rowland SmallBullseye (uncredited)
Ayesha HussainPsylocke (uncredited)
Jessica WalkerArclight (uncredited)
Harry HollandHaroldpool (uncredited)
Kevin FortinZenpool (uncredited)