Cailey FlemingBea
Ryan ReynoldsCal
John KrasinskiDad / Marshmallow (voice)
Fiona ShawGrandmother
Steve CarellBlue (voice)
Phoebe Waller-BridgeBlossom (voice)
Louis Gossett Jr.Lewis (voice)
Alan KimBenjamin
Liza Colón-ZayasJanet
Bobby MoynihanJeremy
Catharine DaddarioBea’s Mom
Audrey HoffmanBea (Ages 3 & 5)
Laquet Sharnell PringleReceptionist
Ed HerbstmanDeli Guy
Barbara AndresWoman Upstairs
Alexander RiveroCustodian
Shauna PinkettHospital Receptionist
Sa'Raya Paris Johnson7 Year-Old Girl
Marta Siteiya MoipeiCoffee Shop Barista
David WeissmannYoung Jeremy
AwkwafinaBubble (voice)
Emily BluntUnicorn (voice)
George ClooneySpaceman (voice)
Bradley CooperIce (voice)
Matt DamonFlower (voice)
Bill HaderBanana (voice)
Richard JenkinsArt Teacher (voice)
Keegan-Michael KeySlime (voice)
Blake LivelyOctopuss (voice)
Sebastian ManiscalcoMagician Mouse (voice)
Christopher MeloniCosmo (voice)
Matthew RhysGhost (voice)
Sam RockwellGuardian Dog (voice)
Maya RudolphAlligator (voice)
Amy SchumerGummy Bear (voice)
Allyson SeegerViola (voice)
Jon StewartRobot (voice)
Craig 'Radioman' CastaldoRadio Man (uncredited)
Mylène FarmerBlossom (French Voice)